BDBM146863 US8957073, 20.1::US8957073, 20.2::US9718803, 20.2

SMILES OCC1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1

InChI Key InChIKey=BWXNFUBGQZFQOI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 146863   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM146863(US8957073, 20.1 | US8957073, 20.2 | US9718803, 20....)
Affinity DataIC50:  1.72nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM146863(US8957073, 20.1 | US8957073, 20.2 | US9718803, 20....)
Affinity DataIC50:  1.14nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM146863(US8957073, 20.1 | US8957073, 20.2 | US9718803, 20....)
Affinity DataIC50:  1.14nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In DepthDetails US Patent