BDBM14712 (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide::A77 1726::CHEMBL973::CHEMBL999::TERIFLUNOMIDE

SMILES: CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=NABQBYDEMLGCEO-UHFFFAOYSA-N

Data: 5 KI  19 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 14712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (malaria parasite P. falciparum)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Mouse)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Mouse)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	435	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		30	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		32	n/a	261	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		2.20E+4	-6.35	1.90E+5	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM14712 (A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...) Show SMILES Show InChI	GoogleScholar	UniChem		2.34E+4	-6.31	1.90E+5	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair