BDBM14742 (S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrrolidin-1-yl]-quinazoline::6,7-Dimethoxy-4-pyrrolidylquinazoline 5::6,7-dimethoxy-4-[(3S)-3-(2-methoxyphenoxy)pyrrolidin-1-yl]quinazoline

SMILES COc1ccccc1O[C@H]1CCN(C1)c1ncnc2cc(OC)c(OC)cc12

InChI Key InChIKey=APOQAWXVAQVYAS-AWEZNQCLSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14742   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14742((S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14742((S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi: >100nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14742((S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Affinity DataKi:  641nM ΔG°:  -8.36kcal/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed