BDBM14769 6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-2H-pyridazin-3-one::6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one::6-(4-Difluoromethoxy-3-methoxy-phenyl)-2H-pyridazin-3-one::6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydropyridazin-3-one::CHEMBL313842::Zaradaverine::Zardaverine

SMILES: COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2

InChI Key: InChIKey=HJMQDJPMQIHLPB-UHFFFAOYSA-N

Data: 34 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 14769   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Rat)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B (Bovine)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Rat)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450] (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489] (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphodiesterase (Trypanosoma cruzi)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14769 (6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair