BDBM14774 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide::CHEMBL193240::DAXAS::ROF::Roflumilast

SMILES: c1cc(c(cc1C(=O)Nc2c(cncc2Cl)Cl)OCC3CC3)OC(F)F

InChI Key: InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N

Data: 4 KI  65 IC50

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 74 hits for monomerid = 14774   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.398	n/a	n/a	n/a	n/a	n/a	n/a
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Adenosine receptor A2b (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Adenosine receptor A2a (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Adenosine receptor A1 (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.398	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.890	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489] (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450] (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] (Human)	BDBM14774 (DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
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