BDBM14779 Pyrazole carboxylic ester 2::ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate

SMILES CCOC(=O)c1c(C)n[nH]c1C

InChI Key InChIKey=BCKARVLFIJPHQU-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14779   

LigandPNGBDBM14779(Pyrazole carboxylic ester 2 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  6.00E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14779(Pyrazole carboxylic ester 2 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  8.20E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14779(Pyrazole carboxylic ester 2 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  8.20E+4nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14779(Pyrazole carboxylic ester 2 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  8.20E+4nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14779(Pyrazole carboxylic ester 2 | ethyl 3,5-dimethyl-1...)
Affinity DataIC50:  8.20E+4nMAssay Description:Inhibition of human PDE4D catalytic domain using [3H]-cAMP as substrate after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair