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BDBM148080 US8962609, DMX-14

SMILES: O=C1Cc2cc(Nc3nccc(n3)-c3ccc(N4CCCC4)c(c3)C#N)ccc2N1

InChI Key: InChIKey=DHPSFJYFPJRCTN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148080   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon


(Homo sapiens (Human))
BDBM148080
PNG
(US8962609, DMX-14)
Show SMILES O=C1Cc2cc(Nc3nccc(n3)-c3ccc(N4CCCC4)c(c3)C#N)ccc2N1
Show InChI InChI=1S/C23H20N6O/c24-14-17-11-15(3-6-21(17)29-9-1-2-10-29)20-7-8-25-23(28-20)26-18-4-5-19-16(12-18)13-22(30)27-19/h3-8,11-12H,1-2,9-10,13H2,(H,27,30)(H,25,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<30n/an/an/an/a7.5n/a



Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM148080
PNG
(US8962609, DMX-14)
Show SMILES O=C1Cc2cc(Nc3nccc(n3)-c3ccc(N4CCCC4)c(c3)C#N)ccc2N1
Show InChI InChI=1S/C23H20N6O/c24-14-17-11-15(3-6-21(17)29-9-1-2-10-29)20-7-8-25-23(28-20)26-18-4-5-19-16(12-18)13-22(30)27-19/h3-8,11-12H,1-2,9-10,13H2,(H,27,30)(H,25,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<30n/an/an/an/a7.5n/a



Domainex Limited

US Patent


Assay Description
Inhibitions studies were performed using a time-resolved fluorescence-based Lanthascreen assay. Phosphorylation of a fluorescein-labelled substrate p...


US Patent US8962609 (2015)


BindingDB Entry DOI: 10.7270/Q2D7994P
More data for this
Ligand-Target Pair