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BDBM148182 US8962616, 11

SMILES: Cc1nc(co1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F

InChI Key: InChIKey=XXLOHULFDLSOBC-KTITXKAJSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148182   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 2


(Homo sapiens (Human))
BDBM148182
PNG
(US8962616, 11)
Show SMILES Cc1nc(co1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F
Show InChI InChI=1S/C17H17F2N3O2S/c1-9-21-14(6-23-9)15-4-10-7-25-16(20)22-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,10,15H,4,7-8H2,1H3,(H2,20,22)/t10?,15-,17+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.02E+3n/an/an/an/a4.537



Pfizer Inc

US Patent


Assay Description
This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...


US Patent US8962616 (2015)


BindingDB Entry DOI: 10.7270/Q20Z7216
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM148182
PNG
(US8962616, 11)
Show SMILES Cc1nc(co1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F
Show InChI InChI=1S/C17H17F2N3O2S/c1-9-21-14(6-23-9)15-4-10-7-25-16(20)22-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,10,15H,4,7-8H2,1H3,(H2,20,22)/t10?,15-,17+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 316n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...


US Patent US8962616 (2015)


BindingDB Entry DOI: 10.7270/Q20Z7216
More data for this
Ligand-Target Pair