BDBM14831 3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chlorophenyl)urea::3-(4-chlorophenyl)-1-(2-methyl-5-tert-butyl-pyrazol-3-yl)urea::CHEMBL87277::Dopamine D2 receptor and serotonin 2a receptor::diaryl urea compound 2::diaryl urea inhibitor 1

SMILES: CC(C)(C)c1cc(n(n1)C)NC(=O)Nc2ccc(cc2)Cl

InChI Key: InChIKey=FWIJKWMXNHRSRO-UHFFFAOYSA-N

Data: 3 IC50  4 Kd  1 K_off  2 K_on  1 ITC

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 14831   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.16E+3	n/a	n/a	n/a	7.0	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.16E+3	n/a	n/a	n/a	7.0	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	n/a	1.18E+5	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	0.140	1.18E+5	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.68E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM14831 (diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair