BDBM14832 3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diazabicyclo[3.3.0]octa-2,4-diene::4-[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]pyridine::CHEMBL313417::D3RKN_48::SKF 86002

SMILES Fc1ccc(cc1)-c1nc2SCCn2c1-c1ccncc1

InChI Key InChIKey=YOELZIQOLWZLQC-UHFFFAOYSA-N

Data  8 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14832   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataKd:  180nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  820nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  110nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2022More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of p38 MAP kinase related TNF-alpha release from human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of p38 MAP kinase related interleukin (IL1-beta (cytokine) release from human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  520nMAssay Description:Inhibition of p38 MAP kinase related interleukin (IL1-beta (cytokine) release from human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of p38 MAP kinase related TNF-alpha release from peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed