BDBM149404 AVL-301::CHEMBL3545308::CNX-419::CO-1686::Rociletinib::Tube721::US10167264, Compound CO-1686::US10300058, CO-1686::US10434101, Compound I-4::US11096942, Compound I-4::US8975249, I-4::US9783524, CO-1686

SMILES: CC(=O)N1CCN(CC1)c2ccc(c(c2)OC)Nc3ncc(c(n3)Nc4cccc(c4)NC(=O)C=C)C(F)(F)F

InChI Key: InChIKey=HUFOZJXAKZVRNJ-UHFFFAOYSA-N

Data: 2 KI  60 IC50  1 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 64 hits for monomerid = 149404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [L858R] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3 (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	187	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	211	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	262	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	344	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	412	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	179	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<0.510	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [L858R] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.53E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M] (Human)	BDBM149404 (US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair