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BDBM149489 US8975265, 1-0

SMILES: NC1(CCC1)c1ccc(cc1)-c1nc2ncccn2c1-c1ccccc1

InChI Key: InChIKey=LMBQMEOEJDKMKM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 149489   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM149489
PNG
(US8975265, 1-0)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ncccn2c1-c1ccccc1
Show InChI InChI=1S/C22H20N4/c23-22(12-4-13-22)18-10-8-16(9-11-18)19-20(17-6-2-1-3-7-17)26-15-5-14-24-21(26)25-19/h1-3,5-11,14-15H,4,12-13,23H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 563n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US8975265 (2015)


BindingDB Entry DOI: 10.7270/Q2F18XGG
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM149489
PNG
(US8975265, 1-0)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ncccn2c1-c1ccccc1
Show InChI InChI=1S/C22H20N4/c23-22(12-4-13-22)18-10-8-16(9-11-18)19-20(17-6-2-1-3-7-17)26-15-5-14-24-21(26)25-19/h1-3,5-11,14-15H,4,12-13,23H2
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 348n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US8975265 (2015)


BindingDB Entry DOI: 10.7270/Q2F18XGG
More data for this
Ligand-Target Pair