BDBM149941 US8975415, 223::US9242973, 223
SMILES COc1cnc(cn1)C(=O)Nc1ccc2OC(C)(C)C3(CC3)[C@]3(COC(N)=N3)c2c1
InChI Key InChIKey=FVLGCKAZTKQUNT-NRFANRHFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 149941
Affinity DataKi: 61.2nM IC50: 99.1nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
Affinity DataKi: 61.2nM ΔG°: -9.83kcal/mole IC50: 99.1nMpH: 4.4 T: 2°CAssay Description:Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.08E+4nMAssay Description:Test Example 5: The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were perfor...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMT: 2°CAssay Description:Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ
production. Human SK-N-BE(2) neuroblas...More data for this Ligand-Target Pair
Affinity DataIC50: 2.08E+4nMT: 2°CAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair