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BDBM150606 US10238633, Example 280::US8987249, 280::US9713606, 280

SMILES: CC(C)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1

InChI Key: InChIKey=VJGDLRYVNAZRGF-SQTWSKAMNA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 150606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150606
PNG
(US10238633, Example 280 | US8987249, 280 | US97136...)
Show SMILES CC(C)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1/C24H33FN4O/c1-15(2)29-9-7-16(8-10-29)17-3-4-18(22(25)13-17)11-21(14-26)28-24(30)23-19-5-6-20(12-19)27-23/h3-4,13,15-16,19-21,23,27H,5-12H2,1-2H3,(H,28,30)/t19-,20+,21-,23-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 21.2n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys...


US Patent US8987249 (2015)


BindingDB Entry DOI: 10.7270/Q2KP80WG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150606
PNG
(US10238633, Example 280 | US8987249, 280 | US97136...)
Show SMILES CC(C)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1/C24H33FN4O/c1-15(2)29-9-7-16(8-10-29)17-3-4-18(22(25)13-17)11-21(14-26)28-24(30)23-19-5-6-20(12-19)27-23/h3-4,13,15-16,19-21,23,27H,5-12H2,1-2H3,(H,28,30)/t19-,20+,21-,23-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 21.2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ...


US Patent US10238633 (2019)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150606
PNG
(US10238633, Example 280 | US8987249, 280 | US97136...)
Show SMILES CC(C)N1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1/C24H33FN4O/c1-15(2)29-9-7-16(8-10-29)17-3-4-18(22(25)13-17)11-21(14-26)28-24(30)23-19-5-6-20(12-19)27-23/h3-4,13,15-16,19-21,23,27H,5-12H2,1-2H3,(H,28,30)/t19-,20+,21-,23-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 21.2n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)


Article DOI: 10.1016/j.bmcl.2004.05.088
BindingDB Entry DOI: 10.7270/Q21G0P8M
More data for this
Ligand-Target Pair