BDBM15149 1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one::2,3-diphenylquinoxaline 5

SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1

InChI Key InChIKey=VQNOKAIGVHODDW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 15149   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15149(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Affinity DataIC50:  290nMpH: 7.5 T: 2°CAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15149(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Affinity DataIC50:  2.09E+3nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15149(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Affinity DataIC50: >5.00E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15149(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Affinity DataIC50:  2.06E+3nMAssay Description:Inhibition of Akt2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15149(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of Akt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15149(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Affinity DataIC50:  295nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15149(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Affinity DataIC50:  290nMAssay Description:Inhibition of AktMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed