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BDBM151805 US8987445, 241

SMILES: NC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1

InChI Key: InChIKey=WKZUDGPRZCTIIY-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 151805   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM151805
PNG
(US8987445, 241)
Show SMILES NC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc2ccccc2c1C1CC1
Show InChI InChI=1S/C27H22F3N3O4S/c28-27(29,30)37-21-11-5-17(6-12-21)16-33(38(35,36)22-13-9-19(10-14-22)25(31)34)26-24(18-7-8-18)23-4-2-1-3-20(23)15-32-26/h1-6,9-15,18H,7-8,16H2,(H2,31,34)
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.5n/an/an/an/an/a37



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...


US Patent US8987445 (2015)


BindingDB Entry DOI: 10.7270/Q2BZ64R5
More data for this
Ligand-Target Pair