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BDBM15187 3-[(2E)-3-(1H-1,3-benzodiazol-2-yl)prop-2-enoyl]-6-chloro-4-phenyl-1,2-dihydroquinolin-2-one::compound 2::compound 5809365

SMILES: Clc1ccc2[nH]c(=O)c(C(=O)\C=C\c3nc4ccccc4[nH]3)c(-c3ccccc3)c2c1

InChI Key: InChIKey=SBOKKVUBLNZTCT-OUKQBFOZSA-N

Data: 1 KI  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15187   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (human))
BDBM15187
PNG
(3-[(2E)-3-(1H-1,3-benzodiazol-2-yl)prop-2-enoyl]-6...)
Show SMILES Clc1ccc2[nH]c(=O)c(C(=O)\C=C\c3nc4ccccc4[nH]3)c(-c3ccccc3)c2c1
Show InChI InChI=1S/C25H16ClN3O2/c26-16-10-11-18-17(14-16)23(15-6-2-1-3-7-15)24(25(31)29-18)21(30)12-13-22-27-19-8-4-5-9-20(19)28-22/h1-14H,(H,27,28)(H,29,31)/b13-12+
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MMDB

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PC cid
PC sid
UniChem

Patents

Article
PubMed
3.90E+3 -7.37 4.50E+3n/an/an/an/a7.525



The Burnham Institute



Assay Description
The Z-LYTE assay (Invitrogen Corporation) employs a FRET-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated ...


J Med Chem 48: 2278-81 (2005)


Article DOI: 10.1021/jm048962u
BindingDB Entry DOI: 10.7270/Q2KD1W4Z
More data for this
Ligand-Target Pair