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BDBM152294 US8993557, 32

SMILES: Cn1c(cc(C(=O)NCc2cccc(c2)-c2ccc(Cl)cc2)c(O)c1=O)C(F)(F)F

InChI Key: InChIKey=HMZYUBJCQJIPAW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 152294   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))
BDBM152294
PNG
(US8993557, 32)
Show SMILES Cn1c(cc(C(=O)NCc2cccc(c2)-c2ccc(Cl)cc2)c(O)c1=O)C(F)(F)F
Show InChI InChI=1S/C21H16ClF3N2O3/c1-27-17(21(23,24)25)10-16(18(28)20(27)30)19(29)26-11-12-3-2-4-14(9-12)13-5-7-15(22)8-6-13/h2-10,28H,11H2,1H3,(H,26,29)
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.3n/an/an/an/a8.0n/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


US Patent US8993557 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M1Z
More data for this
Ligand-Target Pair