BindingDB logo
myBDB logout

BDBM153217 US8993756, 15-1

SMILES: CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(=C)CF)c3)c12

InChI Key: InChIKey=LBGKSTCCHAQOEK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153217   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM153217
PNG
(US8993756, 15-1)
Show SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(=C)CF)c3)c12
Show InChI InChI=1S/C19H17FN4O3/c1-3-27-19(26)14-9-21-17-15(14)16(22-10-23-17)12-5-4-6-13(7-12)24-18(25)11(2)8-20/h4-7,9-10H,2-3,8H2,1H3,(H,24,25)(H,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.50E+3n/an/an/an/an/a25



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US8993756 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31DJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM153217
PNG
(US8993756, 15-1)
Show SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(=C)CF)c3)c12
Show InChI InChI=1S/C19H17FN4O3/c1-3-27-19(26)14-9-21-17-15(14)16(22-10-23-17)12-5-4-6-13(7-12)24-18(25)11(2)8-20/h4-7,9-10H,2-3,8H2,1H3,(H,24,25)(H,21,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0240n/an/an/an/an/a25



Merck Sharp & Dohme Corp

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US8993756 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31DJ
More data for this
Ligand-Target Pair