BDBM15339 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid::6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid::Biphenquinate::Brequinar::US20240034730, Compound Brequinar

SMILES: Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F

InChI Key: InChIKey=PHEZJEYUWHETKO-UHFFFAOYSA-N

Data: 1 KI  31 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 15339   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	367	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	8.0	30
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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RNA demethylase ALKBH5 (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rat)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	367	n/a	n/a	n/a	n/a	8.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Rat)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	127	n/a	n/a	n/a	n/a	8.0	30
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Replicase polyprotein 1ab (2019-nCoV)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (HCoV-OC43)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (HCoV-229E)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Blood fluke)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Blood fluke)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...) Show SMILES Show InChI	GoogleScholar	UniChem		12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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