BDBM15372 3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide::CHEMBL365617::Compound 11::N-Ethyl-3-(5-Chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide::VER-49009

SMILES CCNC(=O)c1[nH]nc(c1-c1ccc(OC)cc1)-c1cc(Cl)c(O)cc1O

InChI Key InChIKey=HUNAOTXNHVALTN-UHFFFAOYSA-N

Data  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 15372   

TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(CHEMBL365617 | N-Ethyl-3-(5-Chloro-2,4-dihydroxyph...)
Affinity DataIC50: 19nMAssay Description:Binding affinity to Hsp90alpha N-terminal ATPase domain by TR-FRET assay based competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15372(CHEMBL365617 | N-Ethyl-3-(5-Chloro-2,4-dihydroxyph...)
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15372(CHEMBL365617 | N-Ethyl-3-(5-Chloro-2,4-dihydroxyph...)
Affinity DataIC50: 25nMAssay Description:Binding affinity to Hsp90 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15372(CHEMBL365617 | N-Ethyl-3-(5-Chloro-2,4-dihydroxyph...)
Affinity DataIC50: 25nM EC50:  260nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(CHEMBL365617 | N-Ethyl-3-(5-Chloro-2,4-dihydroxyph...)
Affinity DataEC50:  210nMAssay Description:Inhibition of Hsp90alpha in human H1299 cells assessed as HIF-1alpha degradation by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(CHEMBL365617 | N-Ethyl-3-(5-Chloro-2,4-dihydroxyph...)
Affinity DataEC50:  350nMAssay Description:Inhibition of Hsp90alpha in human SKBR3 cells assessed as ErbB2 degradation by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(CHEMBL365617 | N-Ethyl-3-(5-Chloro-2,4-dihydroxyph...)
Affinity DataEC50:  500nMAssay Description:Inhibition of Hsp90alpha in human SKBR3 cells assessed as up-regulation of HSP70 protein by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(CHEMBL365617 | N-Ethyl-3-(5-Chloro-2,4-dihydroxyph...)
Affinity DataIC50: 880nMAssay Description:Inhibition of Hsp90alpha ATPase activity by malachite green ATP-ase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed