BDBM154571 4-Methylthio 2-oxobutyric acid (MTOB)

SMILES CSCCC(=O)C(O)=O

InChI Key InChIKey=SXFSQZDSUWACKX-UHFFFAOYSA-N

Data  1 IC50  2 Kd  2 ITC

PDB links: 6 PDB IDs match this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 154571   

TargetC-terminal-binding protein 2(Homo sapiens (Human))
University Of Massachusetts Medical School

LigandPNGBDBM154571(4-Methylthio 2-oxobutyric acid (MTOB))
Affinity DataKd:  2.96E+6nMpH: 8.5Assay Description:Purified CtBP2 was dialyzed overnight against 500 mL of 50 mM glycylglycine at pH 8.5, 300 mM NaCl, 1 mM EDTA, and 2 mM TCEP, with or without 1.5 mM ...More data for this Ligand-Target Pair
TargetC-terminal-binding protein 2(Homo sapiens (Human))
University Of Massachusetts Medical School

LigandPNGBDBM154571(4-Methylthio 2-oxobutyric acid (MTOB))
Affinity DataIC50:  3.00E+5nMAssay Description:Inhibition of recombinant His6-tagged CtBP2 (31 to 384 residues) (unknown origin) dehydrogenase activity expressed in Escherichia coli BL21-Codonplus...More data for this Ligand-Target Pair
TargetC-terminal-binding protein 1(Homo sapiens (Human))
University Of Massachusetts Medical School

LigandPNGBDBM154571(4-Methylthio 2-oxobutyric acid (MTOB))
Affinity DataKd:  1.26E+6nMpH: 7.5Assay Description:Purified CtBP2 was dialyzed overnight against 500 mL of 50 mM glycylglycine at pH 8.5, 300 mM NaCl, 1 mM EDTA, and 2 mM TCEP, with or without 1.5 mM ...More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 2 hits for monomerid = 154571   

CellC-terminal-binding protein 2 (CtBP2)(Homo sapiens (Human))
University Of Massachusetts Medical School

SyringePNGBDBM154571(4-Methylthio 2-oxobutyric acid (MTOB))
ITC DataΔG°: -3.34kcal/mole ΔH°: -3.34kcal/mole logk: 312
pH: 8.5 T: 20.00°C 
CellC-terminal-binding protein 1 (CtBP1)(Homo sapiens (Human))
University Of Massachusetts Medical School

SyringePNGBDBM154571(4-Methylthio 2-oxobutyric acid (MTOB))
ITC DataΔG°: -3.82kcal/mole −TΔS°: 7.70kcal/mole ΔH°: -11.3kcal/mole logk: 710
pH: 7.5 T: 20.00°C