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BDBM155505 US9006454, I147

SMILES: Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1ccc(cc1)-c1cnccn1

InChI Key: InChIKey=XFGLGTNMXMEMMZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 155505   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM155505
PNG
(US9006454, I147)
Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1ccc(cc1)-c1cnccn1
Show InChI InChI=1S/C19H14N4O2/c1-11-8-14(19(24)25)17-15(9-11)22-18(23-17)13-4-2-12(3-5-13)16-10-20-6-7-21-16/h2-10H,1H3,(H,22,23)(H,24,25)
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MMDB

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PC sid
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Similars

US Patent
n/an/a 8.45E+3n/an/an/an/a8.0n/a



Merck Serono S.A.

US Patent


Assay Description
The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...


US Patent US9006454 (2015)


BindingDB Entry DOI: 10.7270/Q2125RCJ
More data for this
Ligand-Target Pair