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BDBM15631 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((S)-1-phenylethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[(1S)-1-phenylethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6b

SMILES: C[C@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1

InChI Key: InChIKey=DRCOMKWKOTTZJP-AWEZNQCLSA-N

Data: 2 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15631   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM15631
PNG
(4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((S)-1-ph...)
Show SMILES C[C@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H19ClN4O/c1-14(15-6-3-2-4-7-15)26-22(28)20-11-17(12-24-20)21-19(13-25-27-21)16-8-5-9-18(23)10-16/h2-14,24H,1H3,(H,25,27)(H,26,28)/t14-/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
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GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
660n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc



Assay Description
A coupled spectrophotometric assay was used in which ADP generated by ERK2 was converted to ATP by pyruvate kinase with the production of pyruvate fr...


J Med Chem 50: 1280-7 (2007)


Article DOI: 10.1021/jm061381f
BindingDB Entry DOI: 10.7270/Q2BR8QFV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM15631
PNG
(4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((S)-1-ph...)
Show SMILES C[C@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H19ClN4O/c1-14(15-6-3-2-4-7-15)26-22(28)20-11-17(12-24-20)21-19(13-25-27-21)16-8-5-9-18(23)10-16/h2-14,24H,1H3,(H,25,27)(H,26,28)/t14-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc



Assay Description
A coupled spectrophotometric assay was used in which ADP generated by JNK3 was converted to ATP by pyruvate kinase with the production of pyruvate fr...


J Med Chem 50: 1280-7 (2007)


Article DOI: 10.1021/jm061381f
BindingDB Entry DOI: 10.7270/Q2BR8QFV
More data for this
Ligand-Target Pair