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BDBM156342 US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine::US9592230, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine

SMILES: Cc1cc(-c2ccccc2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1

InChI Key: InChIKey=GLDWIIPCINYINM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 156342   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156342
PNG
(US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...)
Show SMILES Cc1cc(-c2ccccc2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C24H22N6/c1-17-15-21(19-11-7-4-8-12-19)30-24(25-17)27-22(28-30)13-14-23-26-20(16-29(23)2)18-9-5-3-6-10-18/h3-12,15-16H,13-14H2,1-2H3
PDB
MMDB

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PC cid
PC sid
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Similars

Article
US Patent
n/an/a 2.80n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2CV4KSH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156342
PNG
(US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...)
Show SMILES Cc1cc(-c2ccccc2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C24H22N6/c1-17-15-21(19-11-7-4-8-12-19)30-24(25-17)27-22(28-30)13-14-23-26-20(16-29(23)2)18-9-5-3-6-10-18/h3-12,15-16H,13-14H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.80n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9018217 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DS1
More data for this
Ligand-Target Pair