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BDBM157141 US9023849, 9

SMILES: CC1(C)C(=O)Nc2nc(nnc12)-n1nc(Cc2ccccc2F)c2ncc(F)cc12

InChI Key: InChIKey=LJTIZJZDFQRQOA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 157141   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM157141
PNG
(US9023849, 9)
Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-n1nc(Cc2ccccc2F)c2ncc(F)cc12
Show InChI InChI=1S/C20H15F2N7O/c1-20(2)16-17(24-18(20)30)25-19(27-26-16)29-14-8-11(21)9-23-15(14)13(28-29)7-10-5-3-4-6-12(10)22/h3-6,8-9H,7H2,1-2H3,(H,24,25,27,30)
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MMDB

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Similars

US Patent
n/an/a 85n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9023849 (2015)


BindingDB Entry DOI: 10.7270/Q2TD9W3Q
More data for this
Ligand-Target Pair