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BDBM157168 US9023865, 14

SMILES: Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3cccnc3)ncc12

InChI Key: InChIKey=WOBNBTMSECOXTK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 157168   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157168
PNG
(US9023865, 14)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3cccnc3)ncc12
Show InChI InChI=1S/C19H17N7O/c1-12-7-14(4-6-21-12)18-15-11-22-17(8-16(15)25-26-18)24-19(27)23-10-13-3-2-5-20-9-13/h2-9,11H,10H2,1H3,(H,25,26)(H2,22,23,24,27)
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MMDB

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PC sid
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Similars

US Patent
n/an/a 1.16n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94CC
More data for this
Ligand-Target Pair