BDBM157762 US9023865, 603

SMILES: CCNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1

InChI Key: InChIKey=DNLXIPWRNRDRHD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 157762   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM157762 (US9023865, 603) Show SMILES CCNC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1 Show InChI InChI=1S/C15H16N6O/c1-3-16-15(22)19-13-7-12-11(8-18-13)14(21-20-12)10-4-5-17-9(2)6-10/h4-8H,3H2,1-2H3,(H,20,21)(H2,16,18,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.01	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp US Patent					Assay Description Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...				US Patent US9023865 (2015) BindingDB Entry DOI: 10.7270/Q2PN94CC
					More data for this Ligand-Target Pair