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BDBM157777 US9023865, 618

SMILES: CC(O)c1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12

InChI Key: InChIKey=ALUKVNKUBCVUGS-PQHZJMOTNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 157777   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM157777
PNG
(US9023865, 618)
Show SMILES CC(O)c1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12
Show InChI InChI=1/C17H19N5O2/c1-10(12-6-4-3-5-7-12)19-17(24)20-15-8-14-13(9-18-15)16(11(2)23)22-21-14/h3-11,23H,1-2H3,(H,21,22)(H2,18,19,20,24)/t10-,11?/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 22.8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94CC
More data for this
Ligand-Target Pair