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BDBM158919 US9034866, 394

SMILES: CC(C)(O)C#Cc1ccc2OCCn3c(Cn4ncc5ccc(cc45)C#N)c(nc3-c2c1)C(N)=O

InChI Key: InChIKey=GTVSMYGCWLURCM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 158919   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 14


(Homo sapiens (Human))
BDBM158919
PNG
(US9034866, 394)
Show SMILES CC(C)(O)C#Cc1ccc2OCCn3c(Cn4ncc5ccc(cc45)C#N)c(nc3-c2c1)C(N)=O
Show InChI InChI=1S/C26H22N6O3/c1-26(2,34)8-7-16-4-6-22-19(11-16)25-30-23(24(28)33)21(31(25)9-10-35-22)15-32-20-12-17(13-27)3-5-18(20)14-29-32/h3-6,11-12,14,34H,9-10,15H2,1-2H3,(H2,28,33)
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Similars

US Patent
180n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)


BindingDB Entry DOI: 10.7270/Q2GX49B0
More data for this
Ligand-Target Pair