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BDBM159029 US9034866, 504

SMILES: C[C@@H]1COc2ccc(cc2-n2nc(cc12)C(N)=O)C#C[C@@](C)(O)c1noc(C)n1

InChI Key: InChIKey=KFAABPNJDKNOJM-SPOIOLBHNA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 159029   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159029
PNG
(US9034866, 504)
Show SMILES C[C@@H]1COc2ccc(cc2-n2nc(cc12)C(N)=O)C#C[C@@](C)(O)c1noc(C)n1
Show InChI InChI=1/C20H19N5O4/c1-11-10-28-17-5-4-13(6-7-20(3,27)19-22-12(2)29-24-19)8-16(17)25-15(11)9-14(23-25)18(21)26/h4-5,8-9,11,27H,10H2,1-3H3,(H2,21,26)/t11-,20-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
14n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)


BindingDB Entry DOI: 10.7270/Q2GX49B0
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159029
PNG
(US9034866, 504)
Show SMILES C[C@@H]1COc2ccc(cc2-n2nc(cc12)C(N)=O)C#C[C@@](C)(O)c1noc(C)n1
Show InChI InChI=1/C20H19N5O4/c1-11-10-28-17-5-4-13(6-7-20(3,27)19-22-12(2)29-24-19)8-16(17)25-15(11)9-14(23-25)18(21)26/h4-5,8-9,11,27H,10H2,1-3H3,(H2,21,26)/t11-,20-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
56n/an/an/an/an/an/a7.2n/a



Genentech Inc

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)


BindingDB Entry DOI: 10.7270/Q2GX49B0
More data for this
Ligand-Target Pair