BDBM16067 dithia macrocycle compound 26::tert-butyl N-[(5R,8S,11R)-5-[(1S,3R)-3-(butylcarbamoyl)-1-hydroxy-3-methylpropyl]-8-methyl-7,10-dioxo-3,13-dithia-6,9-diazabicyclo[13.2.2]nonadeca-1(17),15,18-trien-11-yl]carbamate::tert-butyl [(5R,8S,11R)-5-[(1S,3R)-4-(butylamino)-1-hydroxy-3-methyl-4-oxobutyl]-8-methyl-7,10-dioxo-3,13-dithia-6,9-diazabicyclo[13.2.2]nonadeca-1(17),15,18-trien-11-yl]carbamate
SMILES CCCCNC(=O)[C@H](C)C[C@H](O)[C@@H]1CSCc2ccc(CSC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)N1)cc2
InChI Key InChIKey=MTACWIVLLGYNCN-PPVYVLOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 16067
Affinity DataIC50: 195nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville
Universite De Montreal At Succursale Centre-Ville
Affinity DataIC50: >1.00E+4nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair