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BDBM160958 US9108903, 23

SMILES: OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2Cl)cc1

InChI Key: InChIKey=OOZXERKWFWPVJT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160958   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM160958
PNG
(US9108903, 23)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2Cl)cc1
Show InChI InChI=1S/C20H11Cl3FNO4/c21-14-8-13(19(26)25-12-4-1-10(2-5-12)20(27)28)18(9-15(14)22)29-17-6-3-11(24)7-16(17)23/h1-9H,(H,25,26)(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 33n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair