BDBM161012 US9108905, 1::US9186360, 89

SMILES CC\C(=N/O)\C(\C)=C\c1ccc(F)cc1

InChI Key InChIKey=HKROEBDHHKMNBZ-CHBKHGQFSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 161012   

TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50:  74nMT: 2°CAssay Description:Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50:  98.4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of CA-induced increase in calcium influx incubated for 10 mins pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50:  2.68E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of CA-induced increase in calcium influx incubated for 10 mins pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293F cells assessed as inhibition of AITC-induced increase in calcium influx by FLIPR analysis in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glenmark Pharmaceuticals

US Patent
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
In DepthDetails US Patent