BDBM161012 US9108905, 1::US9186360, 89
SMILES CC\C(=N/O)\C(\C)=C\c1ccc(F)cc1
InChI Key InChIKey=HKROEBDHHKMNBZ-CHBKHGQFSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 161012
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 74nMT: 2°CAssay Description:Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 98.4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glenmark Pharmaceuticals
US Patent
Glenmark Pharmaceuticals
US Patent
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Glenmark Pharmaceuticals
US Patent
Glenmark Pharmaceuticals
US Patent
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 79nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of CA-induced increase in calcium influx incubated for 10 mins pr...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Glenmark Pharmaceuticals
US Patent
Glenmark Pharmaceuticals
US Patent
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 79nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of CA-induced increase in calcium influx incubated for 10 mins pr...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 67nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293F cells assessed as inhibition of AITC-induced increase in calcium influx by FLIPR analysis in ...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glenmark Pharmaceuticals
US Patent
Glenmark Pharmaceuticals
US Patent
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...More data for this Ligand-Target Pair