BDBM161311 US10087143, Compound 96::US10738009, Compound 96::US11673864, Compound 96::US9051270, 96::US9758483, Compound 96

SMILES Fc1ccc(Oc2ccc(cc2)C2CC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1

InChI Key InChIKey=HPURRFIKNKVIFS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 161311   

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161311(US9051270, 96 | US10087143, Compound 96 | US975848...)
Affinity DataIC50: 400nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161311(US9051270, 96 | US10087143, Compound 96 | US975848...)
Affinity DataIC50: 400nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Rat)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161311(US9051270, 96 | US10087143, Compound 96 | US975848...)
Affinity DataIC50: 400nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2016
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161311(US9051270, 96 | US10087143, Compound 96 | US975848...)
Affinity DataIC50: 400nMAssay Description:Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161311(US9051270, 96 | US10087143, Compound 96 | US975848...)
Affinity DataIC50: 400nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent