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BDBM161696 US9051279, 10

SMILES: CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)N(C)C)c1ccc(Cl)cc1CNC(C)=O

InChI Key: InChIKey=APSINCLWOMYKMT-MFUYNUFSSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 161696   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM161696
PNG
(US9051279, 10)
Show SMILES CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)N(C)C)c1ccc(Cl)cc1CNC(C)=O
Show InChI InChI=1S/C31H36ClN3O4/c1-7-19(2)39-29-17-27-21(15-28(29)38-6)16-30(37)35(25-11-9-24(10-12-25)34(4)5)31(27)26-13-8-23(32)14-22(26)18-33-20(3)36/h8-15,17,19,31H,7,16,18H2,1-6H3,(H,33,36)/t19-,31?/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.68E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...


US Patent US9051279 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HMM
More data for this
Ligand-Target Pair