BDBM16173 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride::3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide::Amiloride::Amipramidin::CHEMBL945

SMILES: c1(c(nc(c(n1)Cl)N)N)C(=O)NC(=N)N

InChI Key: InChIKey=XSDQTOBWRPYKKA-UHFFFAOYSA-N

Data: 45 KI  31 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 78 hits for monomerid = 16173   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prothrombin (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Amiloride-sensitive sodium channel subunit alpha (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	776	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.07E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 5 subunit alpha (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Trypsin (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor XI (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tissue-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Plasminogen (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Sodium/hydrogen exchanger 1 (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Plasma kallikrein (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Coagulation factor X (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Vitamin K-dependent protein C (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Mouse)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Acid-sensing ion channel 1 (Rat)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Alpha-ketoglutarate-dependent dioxygenase FTO (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	781	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase D1 (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.88E+3	n/a	n/a	n/a	n/a	7.2	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Plasminogen (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 1 (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Acid-sensing ion channel 3 (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium/hydrogen exchanger 1 (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/hydrogen exchanger (three-toed salamander)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium/hydrogen exchanger 1 (Rat)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium/hydrogen exchanger 1 (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Adenosine receptor A1 (Bovine)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Mouse)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		2.43E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Adenosine receptor A2a (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		3.28E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 2 (Rat)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		5.30E+3	-7.19	n/a	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 1 (Rat)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Protachykinin-1 (Rat)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1A (Rat)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1B (Rat)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine 1D receptor (Bovine)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Rat)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2C (Pig)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 3A (Mouse)	BDBM16173 (3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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