BDBM16253 (3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-[(2-methylpropyl)carbamoyl]propyl]carbamoyl}heptan-4-yl]carbamoyl}-2-methanesulfonylethyl]carbamate::CHEMBL448008::N2-[(2R,4S,5S)-5-{[N-{[(3,5-dimethyl-1H-pyrazol-1-yl)methoxy]carbonyl}-3-(methylsulfonyl)-L-alanyl]amino}-4-hydroxy-2,7-dimethyloctanoyl]-N-(2-methylpropyl)-L-valinamide::pyrazole-bearing inhibitor 5

SMILES: CC(C)CNC(=O)[C@@H](NC(=O)[C@H](C)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CS(C)(=O)=O)NC(=O)OCn1nc(C)cc1C)C(C)C

InChI Key: InChIKey=OFAZWNGNAATRSH-UHFFFAOYSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 16253   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Human)	BDBM16253 ((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	-13.5	n/a	n/a	n/a	n/a	n/a	4.5	37
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Beta-secretase 1 (Human)	BDBM16253 ((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM16253 ((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin D (Human)	BDBM16253 ((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...) Show SMILES Show InChI	GoogleScholar	UniChem		131	-9.76	n/a	n/a	n/a	n/a	n/a	4.5	37
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Cathepsin D (Human)	BDBM16253 ((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...) Show SMILES Show InChI	GoogleScholar	UniChem		131	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 2 (Human)	BDBM16253 ((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...) Show SMILES Show InChI	GoogleScholar	UniChem		356	-9.14	n/a	n/a	n/a	n/a	n/a	4.5	37
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					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM16253 ((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...) Show SMILES Show InChI	GoogleScholar	UniChem		356	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair