BindingDB logo
myBDB logout

BDBM162580 US9687479, 60 2-[3-(5-[(5-chlorothiophen-2-yl)methyl]amino-1H-pyrazol-3-yl)-2-oxo-1,2-dihydropyridin-1-yl]acetonitrile

SMILES: Clc1ccc(CNc2cc(nn2)-c2cccn(CC#N)c2=O)s1

InChI Key: InChIKey=MNJBBEOBPNJSQV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 162580   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM162580
PNG
(US9687479, 60 2-[3-(5-[(5-chlorothiophen-2-yl)meth...)
Show SMILES Clc1ccc(CNc2cc(nn2)-c2cccn(CC#N)c2=O)s1
Show InChI InChI=1S/C15H11ClN5OS/c16-13-4-3-10(23-13)9-18-14-8-12(19-20-14)11-2-1-6-21(7-5-17)15(11)22/h1-4,6,8H,7,9H2,(H,18,20)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+4n/an/an/an/a7.425



VERSEON CORPORATION

US Patent


Assay Description
Human thrombin was obtained from Haematologic Technologies Inc. The chromogenic substrate S-2238 was obtained from DiaPharma. Thrombin was assayed in...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair