BDBM163414 US9687479, 282 2-(5-[(5-chlorothiophen-2-yl)methyl]amino-1-[(2-methoxyphenyl)carbonyl]-1H-pyrazol-3-yl)cyclohexan-1-ol

SMILES COc1ccccc1C(=O)n1nc(cc1NCc1ccc(Cl)s1)C1CCCCC1O

InChI Key InChIKey=HHLABOMECJDCHH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 163414   

TargetPlasma kallikrein(Human)
Verseon

US Patent
LigandPNGBDBM163414(US9687479, 282 2-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 5.50E+3nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Verseon

US Patent
LigandPNGBDBM163414(US9687479, 282 2-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent