BDBM16512 (2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2-carboxamide::(2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chromene-4,4-imidazolidine]-2-carboxamide::CHEMBL84446::Fidarestat::Fidarestat (1)

SMILES: NC(=O)[C@@H]1C[C@]2(NC(=O)NC2=O)c2cc(F)ccc2O1

InChI Key: InChIKey=WAAPEIZFCHNLKK-UHFFFAOYSA-N

Data: 12 IC50  1 Kd  2 ITC

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 16512   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldo-keto reductase family 1 member B1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	16	n/a	n/a	n/a	8.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Rat)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Rat)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member A1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Rat)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member A1 (Pig)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member A1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B1 (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 2 hits for monomerid = 16512

Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
Aldose Reductase (ALR2) Mutant (L300P) (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...)	GoogleScholar			-9.29	7.10	-16.4	6.81	8	24.9
TBA					Details of this binding reaction
Aldose reductase (AR) (Human)	BDBM16512 ((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...)	GoogleScholar			-11.2	6.88	-18.0	8.18	8	24.9
TBA					Details of this binding reaction