BDBM16596 4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimidine-4,6-dicarboxamide::CHEMBL514794::MMP Inhibitor, 4::N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide::Pyrimidine Dicarboxamide Inhibitor, 4

SMILES: Cc1cc(ccc1F)CNC(=O)c2cc(ncn2)C(=O)NCc3ccc(c(c3)C)F

InChI Key: InChIKey=PYFRREJCFXFNRR-UHFFFAOYSA-N

Data: 18 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 16596   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 2B6 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
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Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C8 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	22
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Cytochrome P450 1A2 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM16596 (N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.670	n/a	n/a	n/a	n/a	6.8	25
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					More data for this Ligand-Target Pair