BDBM167181 US9073876, 262::US9073876, 274::US9732093, Compound 274

SMILES COC(=O)c1ccc2oc(COc3c(F)c(ccc3C3CCC3)-c3cnc(N)cn3)nc2c1

InChI Key InChIKey=GYWUSWHRIQXKLR-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 167181   

TargetFlap endonuclease 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM167181(US9073876, 274 | US9073876, 262 | US9732093, Compo...)
Affinity DataKi:  19.6nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetFlap endonuclease 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM167181(US9073876, 274 | US9073876, 262 | US9732093, Compo...)
Affinity DataKi:  19.6nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM167181(US9073876, 274 | US9073876, 262 | US9732093, Compo...)
Affinity DataKi:  19.6nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
US Patent

TargetFlap endonuclease 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM167181(US9073876, 274 | US9073876, 262 | US9732093, Compo...)
Affinity DataKi:  19.6nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetFlap endonuclease 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM167181(US9073876, 274 | US9073876, 262 | US9732093, Compo...)
Affinity DataKi:  19.6nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM167181(US9073876, 274 | US9073876, 262 | US9732093, Compo...)
Affinity DataKi:  19.6nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
US Patent