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BDBM169008 US9079866, 409::US9745328, Compound 409::US9884878, Compound 409

SMILES: Nc1ncc(cn1)-c1ccc(cc1F)-c1cccnc1N

InChI Key: InChIKey=HQRRNVKQAUGFCS-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 169008   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169008
PNG
(US9079866, 409 | US9745328, Compound 409 | US98848...)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1F)-c1cccnc1N
Show InChI InChI=1S/C15H12FN5/c16-13-6-9(12-2-1-5-19-14(12)17)3-4-11(13)10-7-20-15(18)21-8-10/h1-8H,(H2,17,19)(H2,18,20,21)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169008
PNG
(US9079866, 409 | US9745328, Compound 409 | US98848...)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1F)-c1cccnc1N
Show InChI InChI=1S/C15H12FN5/c16-13-6-9(12-2-1-5-19-14(12)17)3-4-11(13)10-7-20-15(18)21-8-10/h1-8H,(H2,17,19)(H2,18,20,21)
PDB
MMDB

Reactome pathway
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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...


US Patent US9745328 (2017)


Article DOI: 10.1021/jm049187l
BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169008
PNG
(US9079866, 409 | US9745328, Compound 409 | US98848...)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1F)-c1cccnc1N
Show InChI InChI=1S/C15H12FN5/c16-13-6-9(12-2-1-5-19-14(12)17)3-4-11(13)10-7-20-15(18)21-8-10/h1-8H,(H2,17,19)(H2,18,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9884878 (2018)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2R78H8P
More data for this
Ligand-Target Pair