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BDBM169469 US9079880, 2

SMILES: COc1ccc(cc1Cl)C(=O)N[C@H](C1CC1)c1cccc(c1)C(=O)Nc1nc2CCN(C)Cc2s1

InChI Key: InChIKey=LCCNJTIEMUTVAZ-HSZRJFAPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 169469   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM169469
PNG
(US9079880, 2)
Show SMILES COc1ccc(cc1Cl)C(=O)N[C@H](C1CC1)c1cccc(c1)C(=O)Nc1nc2CCN(C)Cc2s1
Show InChI InChI=1S/C26H27ClN4O3S/c1-31-11-10-20-22(14-31)35-26(28-20)30-25(33)17-5-3-4-16(12-17)23(15-6-7-15)29-24(32)18-8-9-21(34-2)19(27)13-18/h3-5,8-9,12-13,15,23H,6-7,10-11,14H2,1-2H3,(H,29,32)(H,28,30,33)/t23-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.80n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activity of ROCKII (1-543) kinase was measured utilizing Cambrex PKLight ATP Detection Reagent, a homogeneous assay technology using luciferin-lu...


US Patent US9079880 (2015)


BindingDB Entry DOI: 10.7270/Q25X27QJ
More data for this
Ligand-Target Pair