BindingDB logo
myBDB logout

BDBM170310 US9079913, MI-903

SMILES: CC(C)C[C@H](N)C(=O)O[C@H]1CCC(CC1)NC(=O)[C@@H]1N[C@H](CC(C)(C)C)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21

InChI Key: InChIKey=UYHLRILAHNMBPG-BBHSOHGESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 170310   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM170310
PNG
(US9079913, MI-903)
Show SMILES CC(C)C[C@H](N)C(=O)O[C@H]1CCC(CC1)NC(=O)[C@@H]1N[C@H](CC(C)(C)C)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C35H45Cl2FN4O4/c1-18(2)15-25(39)32(44)46-21-12-10-20(11-13-21)40-31(43)30-28(22-7-6-8-24(37)29(22)38)35(27(42-30)17-34(3,4)5)23-14-9-19(36)16-26(23)41-33(35)45/h6-9,14,16,18,20-21,25,27-28,30,42H,10-13,15,17,39H2,1-5H3,(H,40,43)(H,41,45)/t20?,21-,25-,27+,28-,30+,35-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<3.00E+3n/an/an/an/a7.5n/a



The Regents of the University of Michigan

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors was determined using an optimized, sensitive and quantitative fluorescence polarization-based (FP-based) ...


US Patent US9079913 (2015)


BindingDB Entry DOI: 10.7270/Q2DF6Q0S
More data for this
Ligand-Target Pair