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BDBM171283 US9085555, 713

SMILES: Cc1cc2n(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)Nc3cccc(OC(F)(F)F)c3F)nc(C(N)=O)c2cn1

InChI Key: InChIKey=VZHVEBXTGDORAE-XFJVYGCCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 171283   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM171283
PNG
(US9085555, 713)
Show SMILES Cc1cc2n(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)Nc3cccc(OC(F)(F)F)c3F)nc(C(N)=O)c2cn1
Show InChI InChI=1S/C23H20F4N6O4/c1-10-5-15-12(8-29-10)20(21(28)35)31-32(15)9-18(34)33-14-6-11(14)7-16(33)22(36)30-13-3-2-4-17(19(13)24)37-23(25,26)27/h2-5,8,11,14,16H,6-7,9H2,1H3,(H2,28,35)(H,30,36)/t11-,14-,16+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 260n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...


US Patent US9085555 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36MP
More data for this
Ligand-Target Pair