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BDBM17160 3-(4-{[3-(4-{[(2-acetamidophenyl)carbamoyl]amino}-3-methoxyphenyl)-2-oxo-1,2-dihydropyridin-1-yl]methyl}phenyl)propanoic acid::Pyridone derivative, 6

SMILES: COc1cc(ccc1NC(=O)Nc1ccccc1NC(C)=O)-c1cccn(Cc2ccc(CCC(O)=O)cc2)c1=O

InChI Key: InChIKey=YEJVFAXMJIJZFP-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17160   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Integrin alpha4beta1 (VLA-4)


(Homo sapiens (Human))
BDBM17160
PNG
(3-(4-{[3-(4-{[(2-acetamidophenyl)carbamoyl]amino}-...)
Show SMILES COc1cc(ccc1NC(=O)Nc1ccccc1NC(C)=O)-c1cccn(Cc2ccc(CCC(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H30N4O6/c1-20(36)32-25-7-3-4-8-26(25)33-31(40)34-27-15-14-23(18-28(27)41-2)24-6-5-17-35(30(24)39)19-22-11-9-21(10-12-22)13-16-29(37)38/h3-12,14-15,17-18H,13,16,19H2,1-2H3,(H,32,36)(H,37,38)(H2,33,34,40)
PDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
6.31 -11.1n/an/an/an/an/a7.522



GlaxoSmithKline



Assay Description
J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...


Bioorg Med Chem Lett 16: 5538-41 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.044
BindingDB Entry DOI: 10.7270/Q24Q7S8V
More data for this
Ligand-Target Pair