BDBM171687 US9085576, 443::US9611261, Example 443

SMILES Cc1cc(Cl)cnc1C(=O)Nc1ccc(Cl)c(c1)[C@@]1(CF)N=C(N)O[C@@H]2C[C@H]12

InChI Key InChIKey=PSQSRQVCKJEMIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 171687   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM171687(US9085576, 443 | US9611261, Example 443)
Affinity DataIC50: 37.3nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM171687(US9085576, 443 | US9611261, Example 443)
Affinity DataIC50: 5.17E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent