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BDBM171833 US9085584, 3

SMILES: Cc1ccc2nc(C)c3nnc(-c4cccc(O)c4)n3c2n1

InChI Key: InChIKey=OFBDYPOKLBUABM-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 171833   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM171833
PNG
(US9085584, 3)
Show SMILES Cc1ccc2nc(C)c3nnc(-c4cccc(O)c4)n3c2n1
Show InChI InChI=1S/C16H13N5O/c1-9-6-7-13-16(17-9)21-14(10(2)18-13)19-20-15(21)11-4-3-5-12(22)8-11/h3-8,22H,1-2H3
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MMDB

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Similars

US Patent
n/an/a 411n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For assessing activity of compounds on PDE10 inhibition, the following modifications of the protocol described below are applied: protein amount: ...


US Patent US9085584 (2015)


BindingDB Entry DOI: 10.7270/Q27P8X54
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM171833
PNG
(US9085584, 3)
Show SMILES Cc1ccc2nc(C)c3nnc(-c4cccc(O)c4)n3c2n1
Show InChI InChI=1S/C16H13N5O/c1-9-6-7-13-16(17-9)21-14(10(2)18-13)19-20-15(21)11-4-3-5-12(22)8-11/h3-8,22H,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 155n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For all experiments the Phosphodiesterase [3H]cAMP SPA Enzyme Assay (TRKQ7090, GE Healthcare Europe GmbH) were used. The enzymatic activity of the PD...


US Patent US9085584 (2015)


BindingDB Entry DOI: 10.7270/Q27P8X54
More data for this
Ligand-Target Pair